What is Lucence Cancer Screening?
Lucence Cancer Screening, or LucenceINSIGHT™, is a simple blood test offered in Singapore that detects DNA fragments and other biological markers linked to certain cancers.
LucenceINSIGHT™ allows for early detection of cancer before any symptoms appear. enabling proactive health steps for higher success rates and improved treatment outcomes.
How Does Lucence Cancer Screening Assess Your Cancer Risk?
LucenceINSIGHT™ detects cancer signals in your blood by screening for multiple types of cancer using a multi-cancer early detection (MCED) method. This test analyses circulating tumour DNA (ctDNA) through a highly sensitive sequencing process that includes "mirror barcodes" to reduce errors. It identifies specific DNA changes related to cancer, such as single nucleotide variants, insertions, deletions, and certain types of viral DNA.
In clinical validation studies, LucenceINSIGHT™ demonstrated a detection limit as low as 0.05% for specific mutations, achieving 99% accuracy in detecting cancer markers with an overall sensitivity of 80.9%. Additionally, it can predict the potential tissue of origin for up to 21 cancer types with an accuracy of 87.7%, helping provide a focused understanding of your cancer risk.
How Markers Are Linked to Various Types of Cancer?
LucenceINSIGHT™ identifies markers linked to various types of cancer by detecting specific changes in the DNA found in your blood. These markers are indicators of potential cancer risks, offering insights into early signs of cancer. The test also detects viral DNA, such as HPV-related DNA, which can be associated with certain cancers like head and neck cancers. By identifying both genetic markers and viral DNA, LucenceINSIGHT™ provides a more complete picture of your cancer risk, enabling earlier intervention and more informed decisions about your health.
Recent studies presented at ASCO 2023 and ESMO Asia 2023 show how effective LucenceINSIGHT™ can be. One study, involving over 1,400 patients, demonstrated its high sensitivity and ability to spot cancers that are often missed by traditional screening methods. The research highlighted how the test's precision can make a real difference in detecting cancer earlier, improving the chances of successful intervention.
How is LucenceINSIGHT™ Different from Traditional Tumour Marker Tests in Singapore?
LucenceINSIGHT™ stands apart from traditional tumour marker tests by focusing on cancer-specific DNA changes instead of protein markers. This unique approach offers better accuracy and reliability while addressing the shortcomings of existing tests.
High False Positives
Limited Specificity
Elevated Markers in Non-Cancerous Conditions
Examples of Protein Markers and Their Limitations
Protein markers like CA15-3, CA-125, CEA, PSA, and b-HCG are generally used to monitor response to cancer treatment and to screen for recurrence of certain cancers. However, these markers can also be higher in other health conditions that aren't related to cancer, which can cause confusion.
For example, CA15-3, which is mostly linked to breast cancer, can also be raised in conditions like benign ovarian problems, other breast issues, or liver disease. Similarly, CA-125, a marker for ovarian cancer, can be higher due to other gynaecological problems or inflammation.
CEA, used for colorectal cancer, can also increase in people who smoke or have conditions like ulcerative colitis or liver problems. PSA, a marker for prostate cancer, can be affected by non-cancerous issues like an enlarged prostate, aging, or even activities like cycling or ejaculation.
Finally, b-HCG, which is used for detecting germ cell tumours, can also be raised in situations like pregnancy, marijuana use, or certain hormonal issues. Because of these overlaps, these markers aren’t always reliable for diagnosing cancer and can sometimes lead to unnecessary tests or procedures.
Problems with Traditional Tumour Marker Screening
The diagnosis of heart disease in Singapore typically involves a combination of medical history, physical examination, and diagnostic tests. The specific tests used will depend on your symptoms and suspected type of heart disease.
- Frequent false positives
Studies show that 4 in 10 individuals may experience one or more false positive results over a five-year period. These results can cause significant anxiety and unnecessary worry.
- Markers elevated in non-cancerous conditions
Many tumour markers can be raised due to other factors, such as benign conditions, inflammation, or lifestyle factors, which increases the chance of misleading results.
- Limited specificity
Traditional tumour marker tests often have specificity levels below 90%, leading to challenges in accurately identifying cancer.
- Need for invasive follow-ups
False positives or unclear results often require additional invasive procedures, such as biopsies or imaging, to confirm or rule out a cancer diagnosis.
How is this Screening Different from Regular
Blood Tests in Singapore?
Unlike regular blood tests or full blood count tests, LucenceINSIGHT™ focuses specifically on cancer markers instead of general health indicators. This test identifies DNA changes related to cancer in your bloodstream and predicts the tissue of origin for up to 21 types of cancer with 88% accuracy.
Benefits of Lucence Cancer Screening
Early Risk Assessment
LucenceINSIGHT™ provides an early look at your cancer risk through marker analysis, without diagnosing cancer.
Comprehensive Screening
It detects markers for 50 different types of cancer from various organs, including cancers that traditional screenings may miss.
Simple Process
It only requires a single blood test, instead of more invasive procedures like mammograms, colonoscopies, or Pap tests.
Sample Requirements
Only two blood tubes (18mL) are needed, along with a completed order form and consent from both you and your physician. No fasting is required for the test. However, it's recommended to avoid heavy meals at least 4 hours before your blood sample collection.
High Accuracy
LucenceINSIGHT™ uses advanced technology with 99% specificity in detecting cancer markers, ensuring reliable results.
Quick Turnaround
Results are available within 12 to 18 working days, offering timely insights for you to take the next steps.
Key Considerations for Lucence Cancer Screening
- Cancer Signal Detection, Not Diagnosis
LucenceINSIGHT™ looks for signs that might suggest cancer but doesn't directly diagnose it. If the test shows a potential issue, further tests by your doctor are needed to confirm if cancer is present. - Not a Genetic Risk Test
This test doesn’t look at whether you might inherit a higher risk of cancer from your family. It focuses on detecting current signs of cancer in your body. - Supplementary to Standard Screening
LucenceINSIGHT™ should be used in addition to other regular cancer screenings your doctor recommends, not as a replacement for them. - Possibility of False Positives or Negatives
The test may sometimes show a result that isn't accurate—either suggesting cancer when there isn’t any (false positive) or missing cancer that’s actually present (false negative). - Specific Cancer Coverage
LucenceINSIGHT™ only tests for the cancers included in its list. It doesn’t rule out the possibility of other types of cancer that aren't included in the test. - Suitability
The test is not suitable for you if you have been recently diagnosed with cancer. It’s designed for individuals who have been cancer-free for at least three years.
Find the Right Multi-Cancer Early Detection (MCED) Test for You
LucenceINSIGHT™ 5
Cancer Types Covered
- Lung cancer
- Colorectal cancer
- Liver cancer
- Pancreatic cancer
- Thyroid cancer
Who It's For
Suitable for men and women who want a basic yet vital screening for common cancers.
LucenceINSIGHT™ Women’s 7
Cancer Types Covered
- Lung cancer
- Colorectal cancer
- Liver cancer
- Pancreatic cancer
- Thyroid cancer
- Breast cancer
- Ovarian cancer
Who It's For
Ideal for women seeking a screening that includes both general and female-specific cancers.
LucenceINSIGHT™ 12
Cancer Types Covered
For Men:
- Lung cancer
- Colorectal cancer
- Liver cancer
- Pancreatic cancer
- Thyroid cancer
- Bladder cancer
- Prostate cancer
- Stomach cancer
- Gastrointestinal stromal tumours (GIST)
- Nasopharyngeal cancer
- Kidney cancer (clear cell type)
- Esophageal cancer
For Women:
- Lung cancer
- Colorectal cancer
- Liver cancer
- Pancreatic cancer
- Thyroid cancer
- Breast cancer
- Ovarian cancer
- Stomach cancer
- Gastrointestinal stromal tumours (GIST)
- Nasopharyngeal cancer
- Cervical cancer
- Endometrial cancer
Who It's For
Designed for individuals seeking a wider cancer screening option, covering multiple common and significant types.
LucenceINSIGHT™ 50
Cancer Types Covered
- Broad coverage of major cancers, including lung, colorectal, liver, pancreatic, breast, ovarian, and thyroid cancers
- Screening for cancers of the bladder, prostate, and kidney (clear cell type)
- Inclusion of rare cancers such as those in the small intestine, soft tissue, and vulva
- Detection of blood-related cancers like acute myeloid leukaemia and non-Hodgkin lymphoma
- Screening for cancers of the bones, skin, and more
Who It's For
Highly suitable for individuals aged 40 and above or those with a family history of cancer. This is the most comprehensive package for thorough cancer screening.
LucenceINSIGHT™ 5
$1028
LucenceINSIGHT™
Women’s 7
$1298
LucenceINSIGHT™ 12
$2300
LucenceINSIGHT™ 50
$4200
Prices are accurate as of
Lucence Cancer Screening
FAQs
Health is for everyone
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