Lucence Cancer Screening, or Lucence INSIGHT™, is a blood test offered in Singapore that helps identify your cancer risks by detecting markers linked to cancer. Instead of diagnosing cancer, Lucence INSIGHT™ examines these markers to offer insights into any early changes in your body that could suggest an increased cancer risk, giving you the opportunity to take health precautions early.
What is Lucence Cancer Screening?
Lucence Cancer Screening is a simple blood test designed to detect DNA fragments and other biological markers linked to certain cancers. Instead of diagnosing cancer outright, LucenceINSIGHT™ scans for markers that may indicate a heightened cancer risk. This information helps guide you toward proactive health steps and a personalised care plan, all while avoiding more invasive testing.
By focusing on early detection, LucenceINSIGHT™ offers a way for you to monitor your health before any clear signs of cancer appear.
How Does Lucence Cancer Screening Assess Your Cancer Risk?
LucenceINSIGHT™ detects cancer signals in your blood by screening for multiple types of cancer using a multi-cancer early detection (MCED) method. This test analyses circulating tumour DNA (ctDNA) through a highly sensitive sequencing process that includes "mirror barcodes" to reduce errors. It identifies specific DNA changes related to cancer, such as single nucleotide variants, insertions, deletions, and certain types of viral DNA.
In clinical validation studies, LucenceINSIGHT™ demonstrated a detection limit as low as 0.05% for specific mutations, achieving 99% accuracy in detecting cancer markers with an overall sensitivity of 80.9%. Additionally, it can predict the potential tissue of origin for up to 21 cancer types with an accuracy of 87.7%, helping provide a focused understanding of your cancer risk.
LucenceINSIGHT™ Cancer Signal Prediction
LucenceINSIGHT™ can help pinpoint the possible origins of a cancer signal, predicting up to two potential cancer sites. The test focuses on 20 key cancer types, which include:
- Lung
- Colon
- Liver
- Pancreas
- Breast
- Stomach
- Nasopharynx
- Gastrointestinal Tract
- Cervix
- Endometrium (Uterus)
- Prostate
- Kidney
- Bladder
- Lymphoplasmacytic Lymphoma
- Eye
- Stomach
- Head and Neck
- Myeloid (Blood)
- Bladder
- Non-Hodgkin Lymphoma
- Oropharynx (Throat)
- Skin
If the test detects a potential cancer signal but it doesn't match any of the cancer types included in the screening, or if the genetic change (mutation) identified affects multiple organs, the results might not be conclusive.
For example, mutations like TP53 can cause problems in several different organs, which makes it harder to pinpoint the exact source of the cancer signal. In these cases, the test result may be "indeterminate," meaning the source of the cancer risk isn't clear. To get more precise information, additional tests would be necessary to figure out which cancer, if any, is involved and where it might be originating.
How Markers Are Linked to Various Types of Cancer?
LucenceINSIGHT™ identifies markers linked to various types of cancer by detecting specific changes in the DNA found in your blood. These markers are indicators of potential cancer risks, offering insights into early signs of cancer. The test also detects viral DNA, such as HPV-related DNA, which can be associated with certain cancers like head and neck cancers. By identifying both genetic markers and viral DNA, LucenceINSIGHT™ provides a more complete picture of your cancer risk, enabling earlier intervention and more informed decisions about your health.
Recent studies presented at ASCO 2023 and ESMO Asia 2023 show how effective LucenceINSIGHT™ can be. One study, involving over 1,400 patients, demonstrated its high sensitivity and ability to spot cancers that are often missed by traditional screening methods. The research highlighted how the test's precision can make a real difference in detecting cancer earlier, improving the chances of successful intervention.
How is this Screening Different from Regular
Blood Tests in Singapore?
Unlike regular blood tests or full blood count tests, LucenceINSIGHT™ focuses specifically on cancer markers instead of general health indicators. This test identifies DNA changes related to cancer in your bloodstream and predicts the tissue of origin for up to 21 types of cancer with 88% accuracy.
Benefits of Lucence Cancer Screening
Risk Assessment, Not Diagnosis
LucenceINSIGHT™ provides an early look at your cancer risk through marker analysis, without diagnosing cancer.
Comprehensive Screening
It detects markers for 50 different types of cancer from various organs, including cancers that traditional screenings may miss.
Simple Process
It only requires a single blood test, instead of more invasive procedures like mammograms, colonoscopies, or Pap tests.
Sample Requirements
Only two blood tubes (18mL) are needed, along with a completed order form and consent from both you and your physician. No fasting is required for the test. However, it's recommended to avoid heavy meals at least 4 hours before your blood sample collection.
High Accuracy
LucenceINSIGHT™ uses advanced technology with 99% specificity in detecting cancer markers, ensuring reliable results.
Quick Turnaround
Results are available within 12 to 18 working days, offering timely insights for you to take the next steps.
Key Considerations for Lucence Cancer Screening
- Cancer Signal Detection, Not Diagnosis
LucenceINSIGHT™ looks for signs that might suggest cancer but doesn't directly diagnose it. If the test shows a potential issue, further tests by your doctor are needed to confirm if cancer is present. - Not a Genetic Risk Test
This test doesn’t look at whether you might inherit a higher risk of cancer from your family. It focuses on detecting current signs of cancer in your body. - Supplementary to Standard Screening
LucenceINSIGHT™ should be used in addition to other regular cancer screenings your doctor recommends, not as a replacement for them. - Possibility of False Positives or Negatives
The test may sometimes show a result that isn't accurate—either suggesting cancer when there isn’t any (false positive) or missing cancer that’s actually present (false negative). - Specific Cancer Coverage
LucenceINSIGHT™ only tests for the cancers included in its list. It doesn’t rule out the possibility of other types of cancer that aren't included in the test. - Suitability
The test is not suitable for you if you have been recently diagnosed with cancer. It’s designed for individuals who have been cancer-free for at least three years.
Lucence Cancer Screening
FAQs
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